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Doctoral in Chemistry: Dissertation Defense
Monday, July 7thÌýat 12:00pm
Old Dominion 91¶ÌÊÓƵÌý
Room: The CAVE (ECSB 1202)
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"Structural Insights into the Enterovirus Replication Platform: A Potential Antiviral Target for Inhibiting Viral Replication"
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Presented by:
Morgan Daniels
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Enteroviruses are known for causing a wide range of illnesses and conditions, including poliomyelitis, viral myocarditis, and the common cold, with no antiviral treatment available. To aid in the development of effective antiviral therapies against enteroviruses, it is essential to better understand the role of the cloverleaf structure in viral replication. Enterovirus replication proceeds through a relatively conserved mechanism that utilizes a cloverleaf-like secondary structure at the 5’ end of the viral genome and the 3’ end of the template strand. This dissertation aims to deepen our understanding of the enterovirus replication platform through three projects.ÌýÌý
First, the 5’CL of 209 enterovirus serotypes was analyzed using bioinformatic techniques to identify six 5’CL isoforms. Second, the importance of solution studies for structural analysis was established, thus illustrating the value of combining crystallography with solution studies in conformation exploration. Finally, Coxsackievirus B3 3’CL was observed to exhibit a more open structure with a cH or H folding motif, resembling previously published 5’CL models. Overall, the work presented in this dissertation contributes valuable insights into the structural properties and conservation of the enterovirus cloverleaf, enhancing our understanding of the potential of the 5’CL or 3’CL as an antiviral target.
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