Chris Platsoucas

D.Sc. in Molecular Biology and Genetics, Democritus 91����Ƶ of Thrace, (2008)

Ph.D. in Nutritional Biochemistry and Metabolism, Massachusetts Institute of Technology, (1978)

B.S. in Chemistry, 91����Ƶ of Patras, (1973)

Articles

Sakkas, L. I. . and Platsoucas, C. D. (2010). T-cells and B-cells in Systemic Sclerosis. Current Rheumatology Reviews 6 , pp. 276-282.

Heckel, M. C. ., Wolfson, A., Slachta, C. A. ., Schwarting, R., Salgame, P., Katsetos, C. D. . and Platsoucas, C. D. (2010). Human breast tumor cells express IL-10 and IL-12p40 transcripts and proteins, but do not produce IL-12p70. Cellular Immunology.

Pappas, J., Wolfson, A. D., Jung, W., Oleszak, E. S., Helm, C. W., Freedman, R. S., Tsygankov, A. Y. and Platsoucas, C. D. (2009). Differential expression of CD3-Zeta message and protein in tumor infiltrating lymphocytes from solid tumor specimens and malignant ascites from patients with ovarian carcinoma. Anticancer Research 29 , pp. 4673-4682.

Kuivaniemi, H., Platsoucas, C. D. and Tilton, 3rd, M. D. . (2008). Aortic Aneurysms: an Immune Disease with a Strong Genetic Component. Circulation 117 , pp. 242-2452.

White, J. V. ., Ryiewski, C., Trinidad, M., Rosenblum, J. and Platsoucas, C. D. (2007). Aortic aneurysm: search for the trigger. Annals of Vascular Surgery 21 , pp. 292-295.

Platsoucas, C. D. and Oleszak, E. S. (2007). Human Autoimmune Diseases are Specific Antigen-Driven T-Cell Diseases: Identification of the Antigens. Immunologic Research 38 , pp. 359-372.

Sakkas, L. I. . and Platsoucas, C. D. (2007). The role of T cells in the pathogenesis of osteoarthritis. Arthritis and Rheumatism. Arthritis and Rheumatism 56 , pp. 409-424.

Sakkas, L. I. ., Chikanza, I. and Platsoucas, C. D. (2006). Systemic sclerosis: The role of immune cells. Nature Clinical Practice Rheumatology 2 , pp. 679-685.

Platsoucas, C. D., Lu, S., Kwaneshiudu, I., Solomides, C., Agelan, A., Ntaolula, N., Purev, E., Li, L. P. ., Kratsios, P., Mylonas, E., Jung, W., Evans, K., Roberts, S., Lu, Y., Layvi, R., Lin, W. L. ., Zhang, X., Gaughan, J., Monos, D. S. ., Oleszak, E. S. and White, J. V. . (2006). The Abdominal Aortic Aneurysm (AAA) is a specific antigen-driven T-cell disease. Annals of the New York Academy of Science 1085 , pp. 224–235.

Monos, D., Pappas, J., Magira, E., Gaughan, J., Aplenc, R., Sakkas, L. I. ., Freedman, R. S. ., Reveille, J. D. . and Platsoucas, C. D. (2005). Identification of HLA-DQalpha and -DRbeta residues associated with susceptibility and protection to epithelial ovarian cancer. Human Immunology 66 , pp. 554-562.

Lin, W. L. ., Fincke, J. E. ., Sharer, L., Monos, D., Lu, S., Gaughan, J., Platsoucas, C. D. and Oleszak, E. S. (2005). Oligoclonal T cells are infiltrating the brain of children with AIDS: Sequence analysis revealed high proportions of identical beta-chain T-cell receptor (TCR) transcripts. Clinical and Experimental Immunology 141 , pp. 338-356.

Pappas, J., Jung, W., Barda, A. K. ., Lin, W. L. ., Fincke, J. E. ., Purev, E., Radu, M., Gaughan, J., Helm, C. W. ., Hernandez, E., Freeman, R. S.. and Platsoucas, C. D. (2005). Substantial proportions of identical b-chain T-cell receptor (TCR) transcripts are present in epithelial ovarian carcinoma tumors (EOC). Cellular Immunology 234 , pp. 81-101.

Sakkas, L. I. ., Koussidis, G., Avgerinos, E., Gaughan, J. and Platsoucas, C. D. (2004). Decreased expression of CD3zeta chain in T cells infiltrating the synovial membrane (SM) of patients with Osteoarthritis (OA). Clinical Diagnostic Laboratory Immunology 11 , pp. 195-202.

Sakkas, L. I. . and Platsoucas, C. D. (2004). Is Systemic Sclerosis an Antigen-driven T-cell Disease? . Arthritis and Rheumatism 50 , pp. 1721-1733.

Oleszak, E. S., Chang, J. R. ., Friedman, H., Katsetos, C. D. . and Platsoucas, C. D. (2004). Theiler's Virus Infection: A Model for Multiple Sclerosis. Clinical Microbiology Reviews 17 , pp. 174-207.

Oleszak, E. S., Hoffman, B. E. ., Chang, J. R. ., Zaczynska, E., Gaughan, J., Katsetos, C. D. ., Platsoucas, C. D. and Neily, H. (2003). Apoptosis of infiltrating T cells in the CNS of mice infected with Theiler's Murine encephalomyelitis virus (TMEV). Virology 315 , pp. 110-123.

Xu, B., Sakkas, L. I. ., Goldman, B. I. ., Jeevanandam, V., Gaughan, J., Oleszak, E. S. and Platsoucas, C. D. (2003). Identical alpha-chain T-cell receptor transcripts are present on T cells infiltrating coronary arteries of cardiac allografts with chronic rejection. Cellular Immunology 225 , pp. 75-90.

Platsoucas, C. D., Fincke, J. E. ., Pappas, J., Jung, W., Heckel, M., Schwarting, R., Magira, E., Monos, D. and Freedman, R. S. . (2003). Immune responses to human tumors: Development of tumor vaccines. Anticancer Research 23 , pp. 1969-1996.

Sakkas, L. I. ., Xu, B., Artlett, C., Lu, S., Jimenez, S. and Platsoucas, C. D. (2002). Oligoclonal T-cell expansion in the skin of patients with systemic sclerosis. Journal of Immunology 168 , pp. 3649-3659.

Lenzi, R., Rosenblum, M., Verscrhaegen, C., Kudelka, A. P. ., Kavanagh, J. J. ., Hicks, M. E. ., Lang, E. A. ., Nash, M. A. ., Garcia, M. E. ., Platsoucas, C. D., Abbruzzese, J. L. . and Freedman, R. S. . (2002). Phase I study of intraperitoneal rh-IL-12 in patients with Mullerian, Gastrointenstinal Primary Malignancies and Mesothelioma. Clinical Cancer Research 8 , pp. 3686-3695.

Xu, B., Sakkas, L. I. ., Slachta, C. A. ., Goldman, B., Jeevanandam, V., Oleszak, E. S. and Platsoucas, C. D. (2001). Apoptosis in chronic rejection of human cardiac allografts. Transplantation 71 , pp. 1137-1146.

Slachta, C. A. ., Jeevanandam, V., Goldman, B., Lin, W. L. . and Platsoucas, C. D. (2001). Coronary arteries with chronic rejection contain oligoclonal T cells. Persistence of clonally expanded T-cell receptor (TCR) transcripts from the early post-transplantation period through chronic rejection. Transplantation Proceedings 33 , pp. 452-455.

Jung, W., Lu, S., Qin, P., Afolabi, A., Slachta, C. A. ., Jeevanandam, V., Goldman, B. and Platsoucas, C. D. (2001). Gamma-chain T-cell receptor (TCR) transcripts are clonally expanded in the coronary arteries from cardiac allografts from patients with chronic rejection. Transplantation Proceedings 33 , pp. 456-458.

Oleszak, E. S., Lin, W. L. ., Legido, A., Melvin, J., Hardison, H., Hoffman, B. E. ., Katsetos, C. D. . and Platsoucas, C. D. (2001). Oligoclonal T cells are present in the CSF of a child with a recurrent disseminated MS-like demyelinating disease following Hepatitis A infection . Clinical and Diagnostic Laboratory Immunology 8 , pp. 984-92.

Wassef, M., Baxter, B. T. ., Chisholm, R. L. ., Dalman, R. I. ., Fillinger, M. F. ., Heinecke, J., Humphrey, J. D. ., Kuivaniemi, H., Parks, W. C. ., Pearce, W. H. ., Platsoucas, C. D., Sukhova, G. K. ., Thompson, R. W. ., Tilson, M. D. . and Zarins, C. K. . (2001). Pathogenesis of Abdominal Aortic Aneurisms: A Multidisciplina Research Program Supported by the National Heart, Lung, and Blood Institute. Journal of Vascular Surgery 34 , pp. 730-8.

Freedman, R. S.., Kudelka, A. P. ., Kavanagh, J. J. ., Verschraegen, C., Edwards, C. L.., Nash, M., Levy, L., Atkinson, E. N. ., Zhang, H., Melichar, B., Patenia, B., Templin, S., Scott, W. and Platsoucas, C. D. (2000). Clinical and biological effects of intraperitoneal injections of recombinant IFN-alpha and recombinant IL-2 with or without tumor infiltrating lymphocytes in patients with ovarian or peritoneal carcinoma . Clinical Cancer Research 6 , pp. 2268-2278.

Slachta, C. A. ., Jeevanandam, V., Goldman, B., Lin, W. L. . and Platsoucas, C. D. (2000). Coronary arteries from human cardiac allografts with chronic rejection contain oligoclonal populations of T cells. Persistence of identical clonally expanded beta-chain T-cell receptor transcripts from the early posttransplantation period (endomyocardial biopsies) to chronic rejection (coronary arteries) . Journal of Immunology 165 , pp. 369-384.

Chang, J. R. ., Zaczynska, E., Katsetos, C. D. ., Platsoucas, C. D. and Oleszak, E. S. (2000). Differential expression of TGF-beta, IL-2 and other cytokines in the CNS of TMEV-infected susceptible and resistant strains of mice. Virology 278 , pp. 346-360.

Melichar, B., Nash, M. A. ., Lienzi, R., Platsoucas, C. D. and Freedman, R. S. . (2000). Expression of costimulatory molecules CD80 and CD86 and their receptors on tumor infiltrating lymphocytes from patients with ovarian carcinoma and other peritoneal carcinomatosis . Clinical and Experimental Immunology 119 , pp. 19-27.

Katsetos, C. D. ., Fincke, J. E. ., Legido, A., Lischer, H. W. ., De Chardarevian, J., Kaye, E. M. ., Platsoucas, C. D. and Oleszak, E. S. (1999). Angiocentric CD3+ T-cell infiltrates in Human immunodeficiency virus type-1-associated central nervous system disease in children . Clinical and Diagnostic Laboratory Immunology 6 , pp. 105-114.

Loercher, A. E. ., Nash, M. A. ., Kavanagh, J. J. ., Edwards, C. L. ., Platsoucas, C. D. and Freedman, R. S. . (1999). Identification of an IL-10-producing, HLA-DR-negative, monocyte subset in the malignant ascites of patients with ovarian carcinoma, which inhibits cytokine protein expression and proliferation of autologous T cells. Journal of Immunology 163 , pp. 6251-6260.

Sakkas, L. I. ., Tourtellote, C., Berney, S., Myers, A. R. . and Platsoucas, C. D. (1999). Increased levels of alternatively spliced IL-4 (IL-4delta2) transcripts in peripheral blood mononuclear cells from patients with systemic sclerosis. Clinical and Diagnostic Laboratory Immunology 6 , pp. 660-664.

Gordinier, M. E. ., Zhang, H., Patenia, R., Atkinson, E. N. ., Levy, L., Nash, M. A. ., Katz, R. L. ., Platsoucas, C. D. and Freedman, R. S. . (1999). Quantitative analysis of transforming growth factor-beta (TGF-) and HLA class I and II in epithelial ovarian cancer . Clinical Cancer Research 5 , pp. 2498-2505.

Lin, W. L. ., Kuzmak, J., Pappas, J., Peng, G., Chernajovsky, Y., Platsoucas, C. D. and Oleszak, E. S. (1998). Amplification of T-cell receptor alpha- and beta-chain transcripts from mouse spleen lymphocytes by the nonpalindromic adaptor polymerase chain reaction. Hematopathology and Molecular Hematology 11 73-88 1998. Hematopathology and Molecular Hematology 11 , pp. 73-88.

Nash, M. A. ., Lienzi, R., Edwards, C. L. ., Kavanagh, J. J. ., Kudelka, A. P. ., Verschraegen, C., Platsoucas, C. D. and Freedman, R. S. . (1998). Differential expression of cytokine transcripts in human epithelial ovarian carcinoma by solid tumour specimens, peritoneal exudate cells containing tumour, tumour-infiltrating lymphocyte (TIL)-derived T-cell lines and established tumour cell lines. Clinical and Experimental Immunology 112 , pp. 172-180.

Sakkas, L. I. ., Johanson, N., Scanzello, C. and Platsoucas, C. D. (1998). Interleukin-12 is expressed by infiltrating macrophages and synovial lining cells in rheumatoid arthritis and osteoarthritis. Cellular Immunology 188 , pp. 105-110.

Freedman, R. S.., Lienzi, R., Kudelka, A., Lawrence, D. D. ., Rosenblum, M. and Platsoucas, C. D. (1998). Intraperitoneal immunotherapy of peritoneal carcinomatosis. Cytokines. . Cellular and Molecular Therapy 4 , pp. 121-140.

Melichar, B., Savary, C., Kudelka, A. P. ., Verschraegen, C., kavanagh, J. J. ., Edwards, C. L. ., Platsoucas, C. D. and Freedman, R. S. . (1998). Lineage-negative human leukocyte antigen-DR+ cells with the phenotype of undifferentiated dendritic cells in patients with carcinoma of the abdomen and pelvis. Clinical Cancer Research 4 , pp. 799-809.

Nash, M. A. ., Lienzi, R., Platsoucas, C. D. and Freedman, R. S. . (1998). Reverse transcription-PCR quantitation of cytokine responses in vivo from specimens containing small numbers of cells during immunotherapy. Journal of Immunological Methods 219 , pp. 169-179.

Sakkas, L. I. ., Scanzello, C., Johanson, N., Burkholder, J., Mitra, A., Salgame, P., Katsetos, C. D. . and Platsoucas, C. D. (1998). T cells and T-cell derived cytokine transcripts in the synovial membrane of patients with osteoarthritis. . Clinical and Diagnostic Laboratory Immunology 5 , pp. 430-437.

Slachta, C. A. ., Jeevanandam, V., Goldman, B. and Platsoucas, C. D. (1998). T cells infiltrating coronary arteries of cardiac allografts with chronic rejection contain clonally expanded T lymphocytes. Transplantation Proceedings 30 , pp. 1002-1004.

Wu, S., Donigan, A., Platsoucas, C. D., Jung, W., Soprano, D. R.. and Soprano, K. J. . (1997). All-trans-retinoic acid blocks cell cycle progression of human ovarian adenocarcinoma cells at late G1. Experimental Cell Research 232 , pp. 277-286.

Yang, J., Mathioudakis, G., Kruzel, E., Angelo, L. S. ., Sakkas, L. I.., Lee, J. L. ., Oleszak, E. S. and Platsoucas, C. D. (1997). An anti-LFA-1 monoclonal antibody (LDA-8) induces cellular aggregation of human lymphoblastoid cell lines and peripheral blood lymphocytes . Hematopathology and Molecular Hematology 11 , pp. 29-40.

Lee, J. E. ., Reveille, J. D. . and Platsoucas, C. D. (1996). Association of HLA-DQB1*0301 with Malignant Melanoma. Journal of Immunotherapy 19 , pp. 381-383.

Kooi, S., Zhang, H., Patenia, R., Edwards, C. L. ., Platsoucas, C. D. and Freedman, R. S. . (1996). HLA class I expression on human ovarian carcinoma cells correlates with T-cell infiltration in vivo and T-cell expansion in vitro in low concentrations of recombinant interleukin-2. Cellular Immunology 174 , pp. 116-128.

Freedman, R. S.., Gibbons, J. A. ., Giedlin, M., Kudelka, A., Kavanagh, J. J. ., Edwards, C. L. ., Nash, M. A. . and Platsoucas, C. D. (1996). Immunopharmacology and cytokine production of a low dose schedule of intraperitoneally administered human recombinant interleukin-2 in patients with advanced epithelial ovarian carcinoma. Journal of Immunotherapy 19 , pp. 443-451.

Freedman, R. S.., Platsoucas, C. D. and Deisseroth, A. B.. (1996). Use of a retroviral vector to study the trafficking patterns of purified ovarian tumor-infiltrating lymphocytes (TIL) used in intraperitoneal adoptive immunotherapy of ovarian cancer patients - A pilot study. Human Gene Therapy 7 , pp. 1351-1365.

Book Chapters

Platsoucas, C. D. and Oleszak, E. S. (1998). "Structure and function of the trimolecular complex: T-cell receptor/peptide/MHC" Current Topics in Biochemistry (pp. 57-71) Thessaloniki: Aristotelian 91����Ƶ of Thessaloniki, Laboratory of Biochemistry Press.

Freedman, R. S.., Kudelka, A. P. ., Verscrhaegen, C. F.. and Platsoucas, C. D. (1998). Progress toward tumor-specific immunity in carcinomas of the ovary and breast Cancer in Women (pp. 30-53) Oxford, London, Berlin, Tokyo: Blackwell Science Publication.

Conference Proceeding

Platsoucas, C. D. (2001). Perspectives on the Application of Genomics, Transcriptomics (DNA Arrays), and Proteinomics to the Diagnosis and Treatment of Cancer (pp. 307-311) . Proceedings of First Annual Congress of Clinical Oncology, Thessaloniki, Greece,.

Platsoucas, C. D. (1997). Biological therapies of cancer based on T lymphocytes (pp. 130-134) Proceedings of the 15th Annual Meeting of the Hellenic Association of Immunology.

Presentations

Platsoucas, C. D. (September , 2001). Perspectives on the Application of Genomics, Transcriptomics (DNA Arrays), and Proteinomics to the Diagnosis and Treatment of Cancer First Annual Congress of Clinical Oncology Thessaloniki, Greece.

Platsoucas, C. D. ( 1997). Biological therapies of cancer based on T lymphocytes 15th Annual Meeting of the Hellenic Association of Immunology Thessaloniki, Greece.

• 2009: D. Sc, Honoris Causa, Molecular Biology and Genetics, Democritus 91����Ƶ of Thrace, Alexandroupolis, Greece
• 2002: Medal of the 91����Ƶ of Patras for Scientific Achievement, 91����Ƶ of Patras, Patras, Greece
• 1993: Laura H. Carnell Professor of Medicine, Temple 91����Ƶ School of Medicine
• 1992: Hubert L. and Olive Stringer Professorship in Cancer Research, The 91����Ƶ of Texas M. D. Anderson Cancer Center
• 1991: Ashbel Smith Professorship, The 91����Ƶ of Texas M. D. Anderson Cancer Center
• 1991: Dean's Teaching Excellence Award, Graduate School of Biomedical Science, Graduate School of Biomedical Science, The 91����Ƶ of Texas Health Science Center at Houston
• 1978: National Research Service Award,
• 1973: NATO/EMBO International Summer School of Molecular Biology, Tuition Award, NATO/EMBO
• 1969: Scholarships, Greek 91����Ƶ Scholarship Foundation